Tropomyosin is a long, thin protein that helps regulate the interaction between actin and myosin filaments. It lies along the actin filaments and blocks the binding sites for myosin. When a nerve impulse triggers a muscle contraction, a molecule called calcium ions is released into the muscle cell. This causes troponin to bind to actin and move.. Once the calcium ions concentration falls below a certain level, no more contraction cycles can occur. The myosin-binding sites are hidden, and the skeletal muscle relaxes. Energy Sources. The contraction of skeletal muscle requires energy in the form of ATP. This ATP is used by muscle for three major purposes;
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Nature Reviews Molecular Cell Biology 9, s6-s7 (2008) doi:10.1038/nrm2581. Goody, R. S. The missing link in the muscle cross-bridge cycle. Nature Structural Molecular Biology 10, 773-775 (2003.. This is known as the sliding filament model of muscle contraction and occurs via the following process: An action potential arrives at the neuromuscular junction. Calcium ions are released from the sarcoplasmic reticulum (SR) Calcium ions bind to troponin molecules, stimulating them to change shape. This causes troponin and tropomyosin proteins.
